© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 9, 710-715,
May 2, 2001
© 2001 Oxford University Press
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Serum Hormones and the Alcohol–Breast Cancer Association in Postmenopausal Women
Affiliations of authors: J. F. Dorgan, Fox Chase Cancer Center, Philadelphia, PA; D. J. Baer, J. T. Judd, E. D. Brown, B. A. Clevidence, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD; P. S. Albert (Division of Cancer Treatment), D. K. Corle (Division of Cancer Prevention), W. S. Campbell, A. A. Tejpar, P. R. Taylor (Division of Clinical Science), National Cancer Institute, Bethesda, MD; T. J. Hartman, Department of Nutrition, Pennsylvania State University, University Park; C. A. Giffen, Information Management Services, Inc., Silver Spring, MD; D. W. Chandler, Esoterix Endocrinology, Inc., Calabasas Hills, CA; F. Z. Stanczyk, Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
Correspondence to: Joanne F. Dorgan, M.P.H., Ph.D., Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, PA 19111 (e-mail: JF_Dorgan{at}fccc.edu).
Background: Alcohol ingestion is associated with an increased risk of breast cancer in most epidemiologic studies. Results, however, are heterogeneous at lower levels of alcohol intake, and a biologic mechanism for the association has not been clearly identified. To determine whether alcohol consumption by postmenopausal women elevates serum levels of hormones associated with an increased risk of breast cancer, we performed a controlled feeding study. Methods: Participants were 51 healthy postmenopausal women not using hormone replacement therapy. Each participant rotated through three 8-week dietary periods in which she consumed 15 or 30 g of alcohol per day or an alcohol-free placebo beverage. The order of assignment to the three alcohol levels was random. During the dietary periods, all food and beverages were supplied by the study, and energy intake was adjusted to keep body weight constant. Levels of estradiol, estrone, estrone sulfate, testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and androstenediol were measured by radioimmunoassays in serum collected at the end of each dietary period. All statistical tests are two-sided. Results: When women consumed 15 or 30 g of alcohol per day, respectively, estrone sulfate concentrations increased by 7.5% (95% confidence interval [CI] = -0.3% to 15.9%; P = .06) and 10.7% (95% CI = 2.7% to 19.3%; P = .009) and DHEAS concentrations increased by 5.1% (95% CI = 1.4% to 9.0%; P = .008) and 7.5% (95% CI = 3.7% to 11.5%; P<.001) relative to levels when women consumed placebo. None of the other hormones measured changed statistically significantly when women consumed alcohol. Conclusions: Results suggest a possible mechanism by which consumption of one or two alcoholic drinks per day by postmenopausal women could increase their risk of breast cancer.
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