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Journal of the National Cancer Institute Advance Access originally published online on May 27, 2008
JNCI Journal of the National Cancer Institute 2008 100(11):768-769; doi:10.1093/jnci/djn185
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© Oxford University Press 2008.

NEWS

Breast Cancer Metastasis: Do Variations in Inherited Genes Make a Difference?

Gail McBride

The first 150 words of the full text of this article appear below.

A network of inherited gene polymorphisms—slightly different forms of the same gene—may predict whether a breast cancer will metastasize, according to new studies in mice by geneticist Kent Hunter, Ph.D., and colleagues at the National Cancer Institute.


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  		Kent Hunter, Ph.D.

 
The most recent study, published in April in the Proceedings of the National Academy of Sciences, focused on one gene called Brd4, which the scientists believe may be one of the main drivers in a network of breast cancer metastasis–related genes. Found in mice and humans, the gene is normally involved in cell proliferation, cell cycle progression, and DNA replication, all of which can go awry in metastasis. It also interacts with another important gene called Sipa1, which is already known to influence breast tumor invasiveness in mice.

The researchers concluded that, when expressed, the genes in this network alter other genes in the breast cancer cells’ extracellular matrix—the . . . [Full Text of this Article]

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European Population Studies

Many Candidates


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