© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 2, 101,
January 20, 1999
© 1999 Oxford University Press
IN THIS ISSUE |
Simian virus 40 (SV40), a polyomavirus that originated in rhesus monkeys, was discovered
as a contaminant of polio vaccines given to millions of people from 1955 through 1963. This
virus has been studied extensively since its discovery and has been shown to induce tumors in
rodents and to transform many types of cultured cells, including human cells. However, it is not
clear whether SV40 produces tumors in humans. Butel and Lednicky (p. 119)
review various aspects of SV40
Viral Vector Boosts Immunity to Tumors
Blocking Oncoprotein Activity
Inducing Kaposi's Sarcoma Cell Death
Antisense: Suppressing the Suppressor?