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JNCI Journal of the National Cancer Institute 2000 92(11):855; doi:10.1093/jnci/92.11.855
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 11, 855, June 7, 2000
© 2000 Oxford University Press

IN THIS ISSUE

Multidrug Resistance and Disulfiram

P-glycoprotein-mediated multidrug resistance complicates cancer chemotherapy and treatment of patients infected with human immunodeficiency virus. Loo and Clarke (p. 898) examined the effects of disulfiram (AntabuseTM), a drug used to treat alcoholism, on cellular sensitivity to drugs and the maturation of P-glycoprotein. In embryonic kidney cells transfected with the P-glycoprotein gene, 100 nM disulfiram increased sensitivity to two cytotoxic agents. In cells with a modified form of the gene, 50 nM disulfiram blocked maturation of the protein. . . . [Full Text of this Article]

Buserelin, Tamoxifen, and Premenopausal Breast Cancer

PTEN Expression as a Diagnostic Marker

Tumor Cell Gangliosides and Tumor Formation

Identification of Individuals With K-ras Mutations


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