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JNCI Journal of the National Cancer Institute 2000 92(11):864-865; doi:10.1093/jnci/92.11.864
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 11, 864-865, June 7, 2000
© 2000 Oxford University Press

NEWS

Almost Serendipity: Alcoholism Drug Reverses Drug Resistance In Vitro

Brian Vastag

Sometimes in science, luck and an open mind count as much as diligence and dedication. Just ask David Clarke, Ph.D., and Tip Loo, M.D., Ph.D., protein structure researchers at the University of Toronto.



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  		Dr. David Clarke

 
Their story starts with a spicy meal, includes a fortuitous encounter with a mislabeled drug, and ends with a discovery that could open an unexpected research agenda. In this issue of the Journal (p. 898), Clarke and Loo report that disulfiram (AntabuseTM), an inexpensive anti-alcoholism drug, blocks cancer drug resistance in cell cultures.

While still preclinical, the Toronto work presents an entirely new route for overcoming one of cancer therapy’s major stumbling blocks. Drug resistance stymies treatment in half or more of all cancer patients. Tumors often shrink during initial chemotherapy, only to regrow more resistant to . . . [Full Text of this Article]

It’s in the Fold

Curried Brainstorm


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