© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 14, 1042-1043,
July 18, 2001
© 2001 Oxford University Press
EDITORIAL |
Lung Epithelial Proliferation: a Biomarker for Chemoprevention Trials?
Affiliation of author: Lung and Upper Aerodigestive Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD.
Correspondence to: Eva Szabo, M.D., National Institutes of Health, 6130 Executive Blvd., Rm. 2132, Bethesda, MD 20892 (e-mail: szaboe@mail.nih.gov).
Despite major advances in our understanding of the molecular pathogenesis of lung cancer, progress in reducing the death rate from lung cancer has been slow. Lung cancer remains the leading cause of cancer death in the United States, resulting in more deaths each year than the next three major causes of cancer death (cancers of the breast, prostate, and colorectum) summed together. In 2001, it is estimated that there will be 169 500 new cases and 157 400 deaths attributable to lung cancer (1). Clearly, control of this tremendous public health burden will require multiple paths of investigation, ranging from primary prevention and early detection to targeted treatment of advanced malignancy.
Chemoprevention, the use of agents to treat the early phases of carcinogenesis and thereby prevent the development of invasive cancer, offers a promising means of controlling lung cancer by intervening during the earlier, potentially treatable phases of
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