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JNCI Journal of the National Cancer Institute 2001 93(9):716-717; doi:10.1093/jnci/93.9.716
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 9, 716-717, May 2, 2001
© 2001 Oxford University Press

CORRESPONDENCE

Re: Characterization of Hereditary Nonpolyposis Colorectal Cancer Families From a Population-Based Series of Cases

D. Gareth Evans, Chu Lee Wu, Shelia Walsh, Isobel Hansen, Loreena Verma, Charmaine Robinson, Reginald Kingston, Eamonn R. Maher

Affiliations of authors: D. G. Evans, Department of Medical Genetics, St. Mary's Hospital, and Centre for Cancer Epidemiology, Christie Hospital, Manchester, U.K.; C.-L. Wu, I. Hansen, Department of Medical Genetics, St. Mary's Hospital; S. Walsh, C. Robinson, R. Kingston, Department of Clinical Studies, Trafford General Hospital, Manchester; L. Verma, E. R. Maher, Section of Medical and Molecular Genetics, University of Birmingham, The Medical School, Edgbaston, U.K.

Correspondence to: Professor D. Gareth Evans, St. Mary's Hospital, Regional Genetic Service, Hathersage Rd., Manchester, M130JH, U.K. (e-mail: gevans@central.cmht.nwcst.nhs.uk).

Peel et al. (1) have reported a low frequency of mismatch repair (MMR) gene defects in a population-based series of colorectal cancers. Previously, we determined the incidence of hereditary nonpolyposis colorectal cancer (HNPCC) by family history of colorectal cancer in a population-based series of colorectal cancers (2).

We now describe a molecular study to estimate the incidence of MMR mutations in an . . . [Full Text of this Article]

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