© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 20, 1563-1568,
October 17, 2001
© 2001 Oxford University Press
REPORT |
Rotating Night Shifts and Risk of Breast Cancer in Women Participating in the Nurses' Health Study
E. S. Schernhammer, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; F. Laden, F. E. Speizer, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Department for Environmental Health, Harvard School of Public Health, Boston; W. C. Willett, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Departments of Epidemiology and Nutrition, Harvard School of Public Health; D. J. Hunter, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, and Harvard Center for Cancer Prevention, Boston; I. Kawachi, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Department of Health and Social Behavior, Harvard School of Public Health; G. A. Colditz, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and Departments of Epidemiology and Nutrition, Harvard School of Public Health, and Epidemiology Program, Dana-Faber/Harvard Cancer Center, Boston.
Correspondence to: Eva S. Schernhammer, M.D., M.P.H., Channing Laboratory, 181 Longwood Ave., Boston, MA 02115 (e-mail: eva.schernhammer{at}channing.harvard.edu).Reprint requests to: Graham A. Colditz, M.D., D.P.H., Nurses' Health Study, Channing Laboratory, 181 Longwood Ave., Boston, MA 02115.
Background: Melatonin shows potential oncostatic action, and light exposure during night suppresses melatonin production. There is little information, however, about the direct effect of night work on the risk of cancer. We investigated the effect of night work in breast cancer. Methods: We examined the relationship between breast cancer and working on rotating night shifts during 10 years of follow-up in 78 562 women from the Nurses' Health Study. Information was ascertained in 1988 about the total number of years during which the nurses had worked rotating night shifts with at least three nights per month. From June 1988 through May 1998, we documented 2441 incident breast cancer cases. Logistic regression models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs), adjusted for confounding variables and breast cancer risk factors. All statistical tests were two-sided. Results: We observed a moderate increase in breast cancer risk among the women who worked 1–14 years or 15–29 years on rotating night shifts (multivariate adjusted RR = 1.08 [95% CI = 0.99 to 1.18] and RR = 1.08 [95% CI = 0.90 to 1.30], respectively). The risk was further increased among women who worked 30 or more years on the night shift (RR = 1.36; 95% CI = 1.04 to 1.78). The test for trend was statistically significant (P = .02). Conclusions: Women who work on rotating night shifts with at least three nights per month, in addition to days and evenings in that month, appear to have a moderately increased risk of breast cancer after extended periods of working rotating night shifts.
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